Thyroid Tumor Invasion and Metastasis
Our research is focused on elucidating the biochemical pathways involved in invasion and metatasis of thyroid tumors.
Genetic Profiling of Thyroid Cancers
Our group is investigating the genetic profiles of thyroid tumors and correlating these profiles with clinical outcomes. Our goal is to develop diagnostic tests that will inform the clinical decision as to whether a small tumor is likely to progress into an invasive cancer. Where tumors evidence a benign genetic profile, patients might be spared surgery and lifelong hormone replacement therapy. The Identification of specific genetic profiles will also help in the development of new therapies.
Genetic Studies of Familial Non-Medullary Thyroid Cancer
Approximately five-percent of non-medullary thyroid cancers are caused by a genetic defect that is passed down through families. Thus far, this gene has not been identified. UCSF researchers are conducting genetic studies in collaboration with the Department of Human Genetics in order to identify the responsible gene or genes. Finding the specific gene(s) will both aid diagnosis and drug development and improve survival.